THE COMPARISONOFCLINICAL EFFECT OF TAMSULOSINANDNIFEDIPINEINMEDICALEXPULSIVE THERAPYOFLOWERURETERALSTONES

The comparison of clinical effect of tamsulosin and nifedipine in medical expulsive therapy of lower ureteral stones. 57 patients with distal uretral stone (size 3- 6 mm) were randomly divided in two groups. Group 1 (29 patient) recivedtamsulosin 0. 4 mg daily and group 2 received ifedipine 30 mg / daily / TDS. Two group receive water 2 lit/ day and supp Indomethacin 100 mg/ Prn. All patients were questioned about the episode of ureteral colic، dose of Indomethacin، rate and time of spontaneous passage of stone. Patients were followed for 28 day. Tamsulosin group passed stones at 6. 29 day and nifedipine group passed stone at 6. 38 day (P= 0. 947). Five patients of Tamsulosin group and four patients of nifedipine g roup haven’t spontaneous passage of stone after 28 day (P= 1). Tamsulosin group use 6. 28 Indomethacin and nifedipine group use 5. 21 Indomethacin in follow - up p e riod (P=0. 403). In Tamsulosin group 3 patients and in nifedipine group 2 patients have drug complication. (P=1). None of differences were statistically significant. Tamsulosin and nifidipine have same effect on distal Ureteral stone. Both are safe and effective in distal Ureteral stone and have low complication. (both dectease analgesic use and time of passage).