Liver Enzyme Alteration

Liver enzyme alteration may be an incidental finding in asymptomatic individuals who have undergone routine laboratory tests. Isolated alteration of liver enzymes in a healthy individual often represent a challenge even for experienced clinicians. In this article we decide to provide a guide to interpreting alterations to liver enzyme levels.Liver enzyme alterations are classified to predominantly hepatocellular or predominantly cholestatic patterns. We review abnormal enzymatic activity within the 2 subgroups, and suggested initial investigations.