Effect of Six Weeks Continuous Aerobic Training on Tumoral Tissue Expression of Vascular Endothelial Growth Factor (VEGF) and Endostatin in Mice with Breast Cancer

Backgrounds and Tumor growth is dependent on Angiogenesis، and angiogenesis happens when angiogenesis factors overcome the anti-angiogenesis factors. Therefore، the purpose of this study was to evaluate the effectiveness of six weeks continuous aerobic training on tumoral tissue expression of VEGF and endostatin in a mice model of breast cancer. Female Balb/c mice (n=20، 5 to 7 weeks old، 18±2 gr weight) were acclimatized with lab condition and their treadmills for two weeks. Mouse adenocarcinoma tumor balk was transplanted subcutaneously and after a week they were divided into two groups: training and controls. Training group underwent an endurance training for six weeks that was a (five bouts per week of treadmill running each 20 min with %50-%68 VO2max). Tumor tissue was removed 48h after the last training bout and the tissue expression of VEGF and endostatin was evaluated by wester blot analysis collected data were analyzed by statistical methods. Results showed that VEGF expression in tumoral tissue was increased significantly in training group (p<0. 05)، but the increment of endostatin was not significant (p≥0. 05). Interestingly tumor enlargement in training group was much lower than control (p≥0. 05). Presumably exercises induce. Tumor tissue shrinkage is not trough reduction of angiogenesis on other cellular and molecular mechanisms play a role.