EFFECTS OF LOW FREQUENCY ELECTROMAGNETIC FIELD ON MCF-7 CANCER CELL LINE

Breast cancer is the most common cancer in women. The aim of this study was to investigate the effects of electromagnetic field on MCF-7 cancer cell line. Materials & M ethods: MCF-7 cell lines and L929 cell line were cultured in RPMI medium containing fetal bovine serum and antibiotics. Cells for 3 hours were exposed to 50 Hz electromagnetic field with intensities of 50، 200 and 400 Gauss. Growth and proliferation and morphological changes were photographed by inverted microscope. Cell viability was determined by MTT assay. The obtained data was statistically analyzed by means of SPSS software (Version 20) and compared with each other by ANOVA and post hoc Tukey. V iability percent of MCF-7 (87. 985±5. 38) and L929 (93. 726±4. 28) cell line that were vicinity of electromagnetic field with intensity of 50 gauss was not significant compared to the control. Viability percent of MCF-7 (41. 342±8. 27) and L929 (44. 649±3. 39) cell line that were vicinity of electromagnetic field with intensity of 200 gauss was significant compared to the control. Viability percent of MCF-7 (24. 381±5. 98) and L929 (30. 627±7. 55) cell line that were vicinity of electromagnetic field with intensity of 400 gauss was significant compared to the control. Electromagnetic field with frequency of 50 Hz and intensities of 200 and 400 gauss was inhibitory effective on the growth and proliferation of MCF-7 and L929 cell line.