Effect of vitamin E supplementation on lipid peroxidation and the antioxidant defense responses following an exhausting aerobic exercise

physical exercise could induce lipid peroxidation as a result of oxidative stress. And intake of antioxidant compound may alleviate this stress by enhancing antioxidant defense. This study aimed to investigate the effect of vitamin E supplementation as an antioxidant on the lipid peroxidation and serum total antioxidant capacity following exhaustive continuous aerobic exercise in wistar rats. 28 wistar rats aged 4 month were assigned randomly into one of 4 groups: rest, rest vitamin E, continuous aerobic exercise, and continuous aerobic exercise-vitamin E. The supplement groups, were administrated a dose of 250 IU per one kilogram of daily intake food for one month of supplementation. All groups were subjected a familiarization treadmill protocol for two weeks. Finally, rats in continuous aerobic exercise groups exercised at 70% vo2 max. The running speed was 20 m/min at a gradient 5%. Serum malon dealdehyde (MDA) and total antioxidant capacity (TAC) were measured. Data were analyzed by one way ANOVA and sheffe post hoc at P<0.05 level. The MDA increased significantly following continuous aerobic exercise (P<0.05) but vitamin E could not decrease significantly the elevated response of MDA following exercise. However The TAC was higher significantly in continuous aerobic vitamin E group compare to the rest group (P<0.01). vitamin E supplementation despite of enhancement of the antioxidant capacity cannot prevent lipid peroxidation following continuous aerobic exercise in wistar rats.