The effect of Antiaging COQ10 plus on the Treatment of Diabetic Neuropathy

One of the important chronic complications of diabetes is the involvement of peripheral nervous system which presents with burning pain and paresthesia and numbness of distal extremities. Painful diabetic neuropathy sometimes may responds to antidepressant or anticonvulsant drugs. One of the recent advances is the using of Coenzyme COQ10. This pilot and prospective randomized study was carried out on diabetic patients with neuropathic symptoms who referred to the clinic or endocrine research center of Ghaem Hospital in 2012-2013. The written Informed consent was obtained from each participant. Neurologic physical examination was done by one neurologist and nerve conduction velocity (NCV) was obtained. Then COQ10 was administered daily. At First 32 patients participated but only 15 cases completed the study. َAfter 3 months the neurologic physical examination and NCV repeated and the results were compared with the previous data by the same neurologist. Overall 15 cases were eligible and evaluated. NCV revealed mild symmetric sensory and motor axonal neuropathy in 4 and moderate in 8 cases, 3 patients had severe neuropathic involvement. NCV results before and after the treatment showed reduction in the number of cases with severe neuropathy which was statistically significant (p=0. 006). FBS and HbA1C significantly reduced after the treatment (P <0. 001) and (p=0. 024) respectively. The effect of COQ10 on other laboratory variables (serum lipids and creatinin) was not significant. Our study showed that COQ10 can be effective on the relief of neuropathic symptoms and significantly reduces neuropathic pain.