The effects of sodium selenite on serum lipid profile and atherogenic indexes in diabetic rats

The prevalence of diabetes is rising in the world. The aim of this study was to determine the possible protective effect of sodium selenite on serum lipid profile and atherogenic indexes in Alloxan-induced Type 1 diabetic rats. Forty Sprage-dawley male rats were divided into four groups randomly; group one, as control, group two, sham (control treated with sodium selenite (1mg/kg)), group three, diabetic untreated, and group four, treated with sodium selenite (1mg/kg), respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized, blood samples were also collected before killing to measure the blood glucose, triglyceride, cholesterol, LDL, VLDL, HDL and serum atherogenic indexes. Sdium selenite inhibited a significant decrease of BG, TG, C, LDL and VLDL. HDL level. Sodium selenite inhibited significantly serum atherogenic indexes level. This study showed that sodium selenite exerts beneficial effects on the BG, lipid profile and atherogenic indexes in alloxan-induced Type 1 diabetic rats.