ORAL VITAMIN E EFFECT ON ASPIRIN -INDUCED GASTRIC ULCERS BY ORAL AND PARENTERAL ADMINISTRATIONS IN RAT

Gastric ulcers are common worldwide that occur due to different agents such as stress، cigarettes، non-steroid anti inflammatory drugs (NSAIDs) administration، and ethanol. NSAIDs are responsible for 15- 25 % all gastric ulcers. This study was done to evaluate the effects of oral vitamin E on oral and intra peritoneal (I. P) aspirin induced-gastric ulcers in rats. This experimental (interventional) study was done on 30 rats weighing 200±20 gr which randomly were divided into 5 groups including the control group، group receiving 200 mg/kg oral aspirin، group receiving 200 mg/kg aspirin as I. P، group receiving 100 mg/kg vitamin E pre oral aspirin administration، and group receiving 100 mg/kg vitamin E pre I. P administration of aspirin groups. Ulcers were evaluated by J. Score method (reported as J. Score±S. E. M. t student)، and ANOVA was used for data analysis. J. Score of IP administration of aspirin was 18. 83±0. 5 and then J. Score of oral administration of aspirin was 16. 1±0. 6، J. score of vitamin E ± I. P administration of aspirin was 8. 6 ± 0. 3 and finally J. score of vitamin E±oral administration of aspirin was 7. 3±0. 4. Significant decrease was considered in ulcers in groups in which oral vitamin E administrated pre aspirin administration (P< 0. 05). Vitamin E decreased aspirin induced gastric ulcers via antioxidant effects.