Increase of pgc-1 alpha gene expression accompanied by left ventricular structural changes caused by endurance training

Endurance activity impresses structure and function of heart and it improve Efficiency of it, at other hand PGC-1α factor increases of biogenesis of heart mitochondria. Therefore the aim of this study was to investigate the effect of endurance training on cardiac expression of pgc-1 alpha gene. For this purpose, 14 rats (113 ± 20 gram) under controlled conditions (temperature, light/dark (12:12) cycle, with ad Libitum access to food and water) were housed and after familiarization (231 ± 24) there were randomly assigned into control (n = 7) and Experimental (n = 7) groups, the experimental group performed a training program (30 m/minute, 50 minutes, 6 session per week for 14-weeks) on motorized treadmill, and then 48 hours after the end of the last session of training program with control group were anesthetized and sacrificed, then the left ventricle of the heart was removed. Real time RT-PCR and sonography method were used to determine of expression levels of pgc-1 alpha gene and structural changes in left ventricle respectively, finally to compare of data t-test was use. the results showed the structural changes occurred in left ventricle due to 14 weeks endurance training which were found by significant increase of stroke volume (P = 0.003) and left ventricle end diastolic diameter (P = 0.008) in experimental group in compare with control group. Finally the rate of left ventricle pgc-1 alpha gene expression was significantly (P =.002) higher in experimental group than control group. Endurance activities in line with the structural and functional changes in the left ventricle (increased stroke volume and left ventricular end diastolic diameter) increase pgc-1 alpha gene expression.