EVALUATION OF ANTIOXIDANT ACTIVITY OF KLOTHO IN HEMODIALYSIS PATIENTS AND RENAL TRANSPLANT RECIPIENTS

The aim of this study was to evaluate serum levels of antioxidant property Klotho by examining 8-hydroxy-2'- deoxyguanosine (8-OHdG), as a marker of oxidative damage in nucleic acids in patients with hemodialysis and kidney transplantation. Serum samples from 45 patients undergoing hemodialysis and 45 patients with stable renal transplant recipients were collected. Klotho levels, 8OHdG, iPTH and vitamin D (25 (OH) D) were measured using standard methods. Klotho level in hemodialysis patients was significantly higher (p&le0.001). Considering the serum levels (8-OHdG), there was no significant difference between the two groups (p=0.242). Serum parathyroid hormone levels in hemodialysis patients was significantly higher while the correlation between serum levels of iPTH and Klotho in none of the two groups were observed. It seems that high levels of Klotho in hemodialysis patients is a secondary response to high levels of parathyroid hormone, or just due to the use of immunosuppressive drugs in renal transplant recipients.