Effects of hydroalchoholic extract of Turmeric (Curcuma longa) Rhizome on the peripheral and visceral pain in mice

Previously it has been shown that Curcuma longa (CL) has anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antiniceceptive activity in neuropathic injury, when it is administered systemically, although the mechanisms that mediate these effects are not clear. The aim of present study was to determine the peripheral and visceral antinoceceptive effects of hydroalchoholic extract of CL on peripheral and visceral neuropathic pain in mice.
This study was conducted using 160 young adult male albino mice (25-30 g.) in 20 groups (n=8). CL (100, 200, and 500 mg/Kg IP), vehicle (VEH), and (Saline) were injected interaperitonealy 30 min before the pain evaluation tests. Acute and chronic pains were assessed by host plate, tail flick and formaline tests models and visceral pain was assessed by writhing test.
Results indicated that CL has analgesic effects on neuropathic pain (p The above findings showed that CL has modulatory effects on peripheral and visceral pains.