Evaluation of the Effectiveness of Ethanolic Extract of Solanum Surattense against Plasmodium Berghei in Comparison with Choloroquine in Sourian Mice Using Invivo Tests

By considering the importance of some medicinal plants that may have some antimalarial activity, an ethanolic extract of Solanum surattense was tested on Plasmodium berghei in sourian mice and a comparison was made with the effect of chloroquine on the same parasite.
Material and In this study 80 sourian mice were divided into 8 groups, each consisting of 10 animals. The first 7 groups were infected with P. berghei and the last group was used as control. The first seven groups were given chloroquine, solanum surattense at four different concentrations (20, 100, 300, 450 mg/kg) and placebo, respectively and the seventh group did not receive any treatment. The evaluation was done by Rane test. In each group the level of parasitaemia was determined on days 4 and 7, and the results compared with values from Day 0 (just before treatment) in order to record the decline in parasitaemia in treated groups.
The results indicated that, although all the four concentrations of the Solanum Surattense extract significantly reduced parasitaemia in the infected subjects, the 450 mg/kg solution showed optimal effectiveness on the parasites in comparison with other concentrations. Results were analyzed using SPSS software and one-way analysis of variance (ANOVA).
We conclude that although the ethanolic extract of Solanum Surattense is not as effective as chloroquine in reducing parasitaemia, it significantly decreases the parasitemia when compared with control and placebo groups.