Role of Adenosine A2A receptors on 6-Hydroxydopmaine-induced catalepsy in rats

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in ageing individuals. This movement disorder caused by degeneration of dopaminergic neurons from the substantia nigra pars compacta (SNc). Caffeine consumption has been proposed to be associated with a reduced risk of Parkinson’s disease and caffeine in rodent models has protective effects. We have shown that caffeine and SCH58261 as A2A receptor antagonists improve motor dysfunctions induced by 6-hydroxydopamine (animal model of Parkinson’s disease) in rats. The present study extends these findings by investigating the role of A2A receptors on motor disorder induced by unilateral infusion of 6-OH-dopamine into the substantia nigra, compact part (SNc) in rat. The experimental study was carried out on 72 male Wistar rats weighing between 180- 200 g. Animals were divided into the groups contain 8 rats per group and were kept in standard condition. 6-OHDA-induced catalepsy was assessed by using bar test. Caffeine (30 mg/kg i.p.) attenuated catalepsy on bar test in parkinsonian rats (P0.05). SCH58261 (2 mg/kg i.p) significantly improved catalepsy in bar test (P