Drug resistance pattern of carbapenem-resistant Acinetobacter baumannii isolated from a referral burn center in northeast of Iran

Acinetobacter baumannii, an opportunistic gram negative bacteria, is a threat in hospital infections, especially in ICU wards due to the high survival ability and talent to get different antibiotic resistance. So far, there are few reports about sensitivity patterns of multi-drug resistant Acinetobacter baumannii (MDR), especially carbapenem resistance from various hospitals in Mashhad, Iran.
In this study 54 strains of MDR from referral burn unit of Imam Reza hospital in Mashhad were collected during October to March 2013. Sensitivity pattern to antibiotics was determined by Kirby-Bauer method for each isolate. Frequency of various genes responsible for resistance to carbapenem was studied for each isolte by PCR method.
The rate of resistance to tested antibiotics was more than 95%. In addition, this study showed the high prevalence of blaVIM, blaIMP, blaTEM, blaADC, OXA-Like23, OXA-Like24, OXA-Like51, OXA-Like58 and ISAba1 genes, that mediated resistance to betalactam antibiotics.
These results indicate that all isolates were resistant to betalactam antibiotics. These results suggest more study on rational usage of carbapenems for treatment of infections by Acinetobacter baumannii.