Antinociceptive effect of heracleum persicum Leaf hydroethanolic extract in diabetic male mice

Pain is a protective sense in tissue injury time. Diabetes mellitus accompanies with undesirable neuropathic side-effects in long term. The aim of this study was to examine analgesic effects of hydroethanolic HeracleumPersicumL. leaf’s extract (HHE) in diabetic and intact male mice.
96 male mice were divided into 9 groups: control, treated by morphine, treated by HHE (100,200 and 400mg/kg,i.p.) , naloxone HHE(200mg/kg) and STZ (60mg/kg, i.p) and STZ HHE(400mg/kg) randomly. To assess the antinociceptive effects of HHE, the animals were examined by tail-flick and writhing tests.
200 and 400 mg/kg of HHE increased pain threshold compared with control group in writhing and till flick tests (p HHE has antinociceptive and anti-diabetic effects. We suggest the analgesic effects of HHE may be due to opioid system and also it effect on prostaglandins synthesis.