Effect of neurotrophic effect of Rifampicin on memory impairment in male Wistar Rat model of ischemia / reperfusion
Backgroundspatial memory impairment is seen after brain ischemic. The hippocampus is one of the most sensitive parts of the brain following ischemia. Oxidative stress and inflammation after cerebral ischemia damage the hippocampal neurons and cause spatial memory disorder. Rifampicin has anti-inflammatory and anti-oxidant effects. This study reviews the neurotrophic effects of the drug following post traumatic brain damage.
MethodsAnimals were divided into 4 groups: control, ischemic-vehicle and experimental. In the experimental group, rifampicin was injected intraperitoneally (20 mg / kg) at the onset of reperfusion and 24 hours after reperfusion. Ischemia / reperfusion was induced by bilateral closure of the common carotid artery for 20 minutes. Morris water maze and nissl staining were used for all groups.
ResultsResults showed that rifampicin (20 mg / kg) reduced the time and distance needed to find a platform in Morris water maze and increase the number of survival pyramidal cells following ischemia. There was a significant difference between the control group and the ischemic and vehicle groups, but this difference was not significant between the control group and the experimental group.
ConclusionIn addition to the neurotrophic effects of Rifampicin on the tissue structure of the CA1 region of the hippocampus, this drug improves the spatial memory function after transient ischemia / reperfusion. Therefore it seems that rifampicin can be considered as one of the appropriate drug for treatment of brain-ischemic.
Journal of Developmental Biology, Volume:9 Issue:4, 2017
83 - 89
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