Correlation of Tissue Eosinophils with Prognosis in Head and Neck Cutaneous Squamous Cell Carcinomas

The skin squamous cell carcinoma (CSCC) is the second most common skin cancer. The correlation between severe tissue eosinophilia with optimal and undesirable prognosis, or even an ineffectiveness effect was related. The aim of the present study was to investigate the correlation between tissue eosinophilia and prognosis in patients with head and neck squamous cell carcinoma.

In this cross-sectional study, 33 patients with squamous cell carcinoma of the pathology department of Shahid Beheshti hospital of University of Babol University of Medical Sciences (age, sex, tumor site) were collected and histopathologic in the vascular and nervous invasions was studied. Numbers of eosinophils (eos.) were counted in 15 successive fields at invasive fronts of HNCSCCs (area of 15 fields=1.2mm2) at×400 magnification with optical microscope. The correlation between the mean number of eosinophils per Mm² and the severity of eosinophilia (mild and severe) and clinical-histopathologic factors was analyzed.
FINDINGS: Mean eos/mm2 was 99.1913±104.39897. Overall survival rate, disease-specific survival rate and disease-free survival rate were %72.72, %61.53% and %84.84, respectively. There was inverse significant correlation between disease-free survival with eos/mm2 (p=0.043). There were no significant correlation between other clinical-histopathologic factors with mean eos/ mm2.There were inverse significant correlations between 5-year overall survival rate and 5-year disease-free survival rate with severity of tissue eosinophilia (p=0.02 and 0.013 respectively).There were not significant correlations between 5-year disease-specific survival and other factors with severity of tissue eosinophilia.

There was inverse correlation between severity of tissue eosinophilia with survival