Effects of Rosa canina L. against ethanol induced hepatotoxicity and nephrotoxicity

Rosa canina L. widely used in Iranian traditional medicine. This study was designed to assess the protective activity of ethanol extract of RC in ethanol-induced hepatotoxicity in rats. In our study, 30 male Wistar rats were divided into 5 groups: control, ethanol (5 g. kg−1), ethanol (5 g. kg−1) + RC1 (200 mg. kg−1), ethanol (5 g. kg−1) + RC2 (400 mg. kg−1) group and RC (400 mg. kg−1). Histopathological evaluation, measurement of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine levels were performed. Ethanol consumption caused a significant increase in the serum levels of AST, ALT, ALP, BUN and creatinine. Co-administration of RC (200 and 400 mg/kg/d) with ethanol, significantly decreased levels of ALT, AST, ALP, BUN and creatinine. The extract (200 and 400 mg/kg/d) ameliorate the histological injuries compare to ethanol group. Our findings suggest a hepatoprotective and renoprotective capability of RC extract against ethanol induced alteration in biochemical and histopathological properties of hepatic and renal tissues.