Psoriasis is one of the most common skin diseases affecting 2-4% of the population. Based on the related literature, patients with psoriasis are at increased risk of developing type 2 diabetes. The present study aimed to compare the patients with psoriasis to healthy individuals in terms of prevalence of diabetes.
This cross-sectional case-control study was carried out in Sina Hospital, Hamadan, Iran. A total of 35 patients with psoriasis were allocated to the case group and 35 healthy subjects who were comparable in terms of age and gender were assigned to the control group. All participants were examined concerning fasting plasma glucose (FPG) and body mass index. In both groups, the FPG≥126 mg/dl indicated diabetes. The collected data were analyzed in SPSS software (version 16.0; SPSS Inc. Chicago, IL). A p-value less than 0.05 was considered statistically significant.
In each group, 19 individuals (54.3%) were male. Mean age in case group was 43±11.5 and in controls was 45.1±12.8 (p-value=0.481). The mean Psoriasis Area and Severity Index (PASI) of the patients was 20.6±12.7 (1.4 to 49.8). The most frequent severity of psoriasis regarding PASI was moderate including 16 patients (45.7%). The mean FPG in the patients was 108±33.6 and in controls 99.6±20.5mg/dl (P=0.755).Eight patients (22.9%) had diabetes while only 3 healthy controls (8.6%) had it (P=0.188). Multivariate logistic regression analysis demonstrated that psoriasis patients with the same gender, BMI and age have almost 4- fold increased risk of developing diabetes rather than healthy controls (P=0.08). As evidenced by the obtained results, eight patients with psoriasis (22.9%) suffered from diabetes, whereas only three (8.6%) of them had diabetes in the control group (P=0.188). Multivariate logistic regression analysis demonstrated that patients with psoriasis had almost 4-fold increased risk of developing diabetes, compared to healthy people (P=0.08).
Based on the findings of the current study, the probable association between type 2 diabetes and psoriasis should be taken into account given hyperglycemia in patients with psoriasis.