Effect of Stachys setifera essential oil on human breast cancer MCF-7 cells line

Breast cancer is the most common cancer among women. One of the approaches to prevent and treat various cancers is to use plant compounds. The aim of this study was to investigate the effect of S. setifera essential oil on MCF-7 human breast cancer cell line and comparing it with Doxorubicin as a known anti-cancer medicine.

Cells are treated by 0.01-0.025 µl/ml of essential oil at at 24, 48 and 72 hours and cell viability and colony formation ability were quantified. Also, essential oil compositin is analyzed by GC-Mass.

The S. setifera essential oil decreased the viability and CFU of cells, significantly. EO IC50 was reported as 0.0206, 0.0175 and 0.0173 µl/ml over 24, 48 and 72 hours. In addition, the S. setifera essential oil GC-Mass analysis showed that most compounds are related to hydrocarbon alkanes and terpenoids.

Probably the essential oil cytotoxicity effects are related to hydrocarbon alkanes and terpenoids compounds.