THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING AND THYME EXTRACT ON OXIDATIVE STRESS AND ANTIOXIDATIVE FACTORS IN DIABETIC RATS

The prevalence of type 2 diabetes is increasing due to lifestyle changes, increasing prevalence of obesity and inactive physical activity, and glucose modulation is of great importance in these individuals. Thyme was studied on type 2 diabetic rats by streptozotocin and high fat diet.

Male Wistar rats weighing 110±10 g were used in this study. The rats were randomly divided into four groups of Thymus + Exercise, Thymus, Exercise and Control groups. The extract was taken 200 g daily through a gavage syringe. Exercise included: Running on a treadmill at a speed of at least 20 m / min and a maximum of 38 m / min for 60 minutes daily, 5 days a week, for 8 weeks. Serum malondialdehyde (MDA), glutathione peroxidase (GTX), superoxide dismutase (SOD), catalase (CAT) were measured by ELISA method.

Serum MDA and CAT levels were significantly higher in the control group (p = 0.002). The results also showed that there was no significant difference between SOD and GPX levels in different research groups (p = 0.790).

Intermittent exercise (HIIT) and thyme extract can improve oxidative and antioxidant balance in diabetic rats.