Assessment of correlation between cell cycle regulatory protein cyclin D1 expression and prognostic factors in prostate carcinoma

The effect of Cyclin D1 expression on prostate cancer has not yet been elucidated. The present study aimed to evaluate the relation of immunohistochemical expression of Cyclin D1 with tumor progression.

In this descriptive cross-sectional study, tissue samples of patients referred to Imam Khomeini, Shahid Baqaei and Golestan hospitals of Ahwaz with confrimed diagnosis of prostate adenocarcinoma and benign prostatic hyperplasia were used. Clinical and demographic data of patients were extracted from hospital records. Immunohistochemical staining was performed using Anticyclin D1 monoclonal antibody.

In this study, 69 patients with prostate cancer and 10 patients with benign prostatic hyperplasia were studied. Mean age of patients was 70 year. Immunohistochemical expression analysis of Cyclin D1 showed that only 6% of patients were negative and 32% had very strong expression.All of the ten patients with benign prostatic hyperplasia were negative. The high (plus plus) expression of cyclin D1 was significantly more frequent in high grade tumors (p = 0.02).

Overall, the findings of this study indicate that the Cyclin D1 marker is broadly increased in prostate malignancy and its upregulation can be related to tumor grade based on Gleason score .