The study of Effects of aqueous extract of flaxseed on feta, placental and Hofbauer cell in BALB /c mice on days 3-6 of pregnancy

Flaxseed (Linum usitatissimum) is an example of the herbs that has been under investigation of including lignin, fber, α-linolenic acid (ALA), omega-3, phytoestrogen and suggested to be used for the treatment of menopausal hot flashes, depression, decrease blood glucose levels, blood lipids level. Since estrogen is one of the factors in pregnancy and the normal concentration of this hormone during pregnancy is essential in the successful copletio. According to the high levels of phytoestrogens in flaxseed, the use of this plant in early pregnancy causes disturbances. That’s why, the effect of aqueous extract of flaxseed on fetal weight, placental weight and the number of hofbauer cell was determined. Nine groups of Balb/c, each includes ten adult females were selected. The experimental groups received (0.05،0.1،0.2،3.75،7.5،15، 21 mg/kg. b. w) of flaxseed. The control group received no medication, and the sham group received only distilled water. The samples were taken at 15 of gestation. Weight of Fetal, placental weight and the number of hofbauer cell measured and analyzed as well. The results were analyzed by Duncan, ANOVA and TUKY test between the control and experimental group. Weight of fetal and placenta in the experimental groups showed statistically signifcant decrease comparing with control group (P<0.05). Flaxseed probably caused decreasing in developmental of fetal and placenta. The increasing number of hofbauer cell confrmed that flaxseed is an external factor.