The Effect of Eight Weeks of High Intensity Interval Training on Plasma Glucagon, GLP-1 and Lipid Indicators in Non-Alcoholic Fatty Liver Patients

Non-alcoholic fatty liver disease is a chronic disease that is associated with the accumulation of fats in the liver. Regular exercise can be considered as an effective strategy in the treatment of non-alcoholic fatty liver disease. The aim of this study was to evaluate the effect of eight weeks of intense interval training on plasma levels of glucagon, GLP-1 and blood lipid indices in patients with non-alcoholic fatty liver.

The present study was a quasi-experimental study in which the study population was women with non-alcoholic fatty liver disease, 25 of whom were randomly divided into two groups of exercise (n = 13) and control (n = 12). Were. Intense intermittent training protocol was performed for 8 weeks and four sessions per week, each session lasting 60 minutes. Blood samples were taken from the brachial vein in pre-test and post-test conditions. Statistical analysis of data was performed using analysis of covariance and paired and independent t-test by spss21 software at a significant level of p <0.05.

After eight weeks of intense interval training, the glucagon, GLP-1 and HDL plasma levels in the training group increased significantly compared to the control group (P<0.05). Also, LDL, TG, TC, insulin resistance index and body fat percentage in the exercise group had a significant decrease compared to the control group (P<0.05).

According to the findings of this study, intense interval training can be suggested as a treatment and prevention strategy for non-alcoholic fatty liver disease.