The Effect of Selenium Supplementation on Glucose Homeostasis and Lipid Profile in Women with Metabolic Syndrome: Randomized, Double-Blind, Placebo-Controlled Trial

Metabolic syndrome refers to a cluster of disorders including abdominal obesity, glucose intolerance, hypertension, hypertriglyceridemia, low HDL) High-density lipoprotein( levels. The metabolic syndrome increases the risk of developing cardiovascular disease and type 2 diabetes. Recently, it has been found that selenium can also be effective in the carbohydrates and fat metabolism. The aim of this study was to evaluate the effects of selenium supplementation on glucose homeostasis parameters and lipid profile in women with metabolic syndrome.

This randomized, double-blind, placebo-controlled trial was conducted among 70 women diagnosed with MS and aged 20-49 years old. Participants were randomly divided into two groups to receive 200 μg per day selenium supplements (N=35) or placebo (N=35) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to quantify glucose, insulin and lipid concentrations.

After 8 weeks of intervention in two groups, there was no significant difference between the two groups in the variables studies include fasting blood sugar (FBS), Insulin, homeostasis model of assessment-insulin resistance (HOMA-IR), Quantitative insulin sensitivity check index (QUICKI), triglyceride, total cholesterol, HDLand LDL cholesterol )Low- density lipoprotein(.

Supplementation of 200 μg of selenium for 8 weeks had no significant effect on glucose homeostasis and lipid profile in the participants with metabolic syndrome.