Effect of High and Moderate Aerobic Exercise on Serum Fibroplast-21 GrowthFactor and Paraoxonase-1 Enzyme Activity in rat with Non-Alcohol-Fatty Liver

Non-alcoholic fatty liver is a fatty liver accumulation that increases the risk of cardiovascular disease, liver carcinoma and diabetes, and physical exercises can possibly reduce liver fat. The purpose of this study was to investigate the effect of eight weeks of aerobic training on high and moderate levels on serum levels of FGF-21 and PON-1 in non-alcoholic fatty liver.

To five equal groups: 1 control(healthy); 2) control(Fatty Liver) ; 3) saline; 4) high intensity exercise; 5) moderate intensity exercises. The period of exercise trainings was performed at 8 weeks, five times a week and 45 minutes in an exercise session. Serum samples were collected 48 hours after the last exercise session and at 12- hour fasting. One-way analysis of variance and Tukey test were used at the level of P

The levels of FGF-21had a significant decrease in the high and moderate intensity exercise groups than the control(Fatty Liver) (P≤0.001). Also, the levels of PON-1 had a significant increase in the high and moderate intensity exercise groups than the control(Fatty Liver) (P≤0.01), but no significantly difference between the two groups was observed.

According to the results of this study, it seems that high and moderate intensity exercise training can decrease FGF-21 and increase paraoxonase-1 serum levels which can result in reduced risk of liver diseases in rat Nonalcoholic Fatty Liver Disease.