Application of Platelet-Rich-Plasma Fibrin-Glue in Preventing of Bleeding in Coronary Artery Bypass Grafting, Review Article

Coronary artery bypass graft (CABG) is a very good option for the treatment of coronary artery occlusion. One of the risks is bleeding from anastomotic site because of suturing disruption which is dangerous for patient. Fibrin glue (FG) is an effective tissue sealant in tissue repair. In the present time, FG has been not used routinely in CABG surgery. The aim of this review article is to evaluate the preventive effect of FG from bleeding in anastomotic site in CABG.

A systematic search in PubMed database was done from February 1999 to February 2019 with these key words: Fibrin glue, surgery and coronary artery bypass. All clinical and experimental studies, which are written in English language and about preventive effect of FG from bleeding in CABG surgery were considered.

The seventy articles were found. Seventeen articles have been used. In Clinical studies, commercial allogenic FG in eleven studies , allogenic FG from single donor in one study, autologous FG in three studies and commercial allogenic & autologous FG in one experimental study were used. Fourteen studies showed that FG is very effective to decrease the bleeding. One study reported that autologous FG can decrease the bleeding better than commercial allogenic FG. One study reported no beneficial effect of FG in decreasing of bleeding. One study reported very adverse effect of FG which caused the mortality in patients.

The use of allogenic and autologous FG is very effective in reducing of bleeding in anastamotic site in CABG.