The effect of different intensities Resistance Training on expression mir-204 and transcription factors of osteogenic, Runx2 and biomechanical properties on bone in Old male Wistar rats

aging is known as low bone mass, resulting in increased risk of fracture. The effects of strength training on the mechanical bone strength and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs). The aim of this study was to determine the effects of compare effects of resistance exercise training protocols with different intensities on microRNA-204 (mir-204) and biomechanical properties in bone Wistar elderly rats.

This experimental study was done on 24 Wistar male rats (23 month old and with an average weight of 437.93 gram). They were randomly divided into three equal groups (n=8) include moderate (60% Maximum voluntary carrying capacity) or high (80% Maximum voluntary carrying capacity) intensity resistance training and control. The two training groups completed eight weeks of training program, five days a week according to resistance protocols. After completing training, expression of mir-204 on bone marrow were measured RT-PCR and Three – point bending test was used to determine bone biomechanical properties.

The statistical analysis was performed using Kruskal-Wallis and one way ANOVA test with significance level of P