Comparison of Interval and Continuous Training on Growth Differentiation Factor 15, Pancreatic beta cell function and insulin resistance in Women with Type 2 Diabetes
Article Type:
Research/Original Article (دارای رتبه معتبر)

Exercise increases glucose intake and is an effective way to control diabetes mellitus. The aim of this study was to investigate the effect of interval and continuous exercise on GDF-15, pancreatic beta cell function and insulin resistance in women with type 2 diabetes.

Materials and Methods

45 women with type 2 diabetes with a mean age of 38.69±3.11 and fasting blood sugar of 9.78±1.25 mmol/l were randomly divided into three groups: continuous exercise, interval exercise and control. Continuous exercise consisted of twelve weeks, 3 sessions per week from 50 to 75% of maximum heart rate. Interval exercise continued from 75 to 90% of maximal heart rate. Sampling was performed before and after the intervention. Dependent t-test was used to compare within-group changes and analysis of covariance was used to compare between groups.


According to the statistical results, in the continuous group, a significant decrease was seen in the post-test compared to the pre-test, and in the interval group, an increase in the level of GDF-15 was observed. There was a significant difference between the mean insulin resistance in the pre-test and post-test periods in the continuous and interval groups compared to the control group. In the continuous and interval groups, there was a significant difference between the mean performance of beta cells in the pre- and post-period periods compared to the control group (P= 0.05).


Performing a period of continuous and interval exercise is effective in improving beta cell function, blood glucose Reduction and improving insulin resistance.

Medical Journal of Mashhad University of Medical Sciences, Volume:64 Issue: 2, 2021
2642 to 2652  
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