Evaluation of the effects of systemic and loacal TXA in reducing bleeding in spine surgeries

One of the methods to control and reduce bleeding in spine surgery is the use of tranexamic acid. The aim is to compare bleeding in intravenous and local administration and determine the protocol of its use in spine surgery to reduce bleeding .

Study was retrospective cross-sectional in the patients undergoing spine surgery in Baqiyatallah Hospital. Inclusion criteria were elective surgery > 3 levels and exclusion criteria were bleeding disorder, dural tear and surgery > 3 hours. The local and intravenous groups were 27 and 22, respectively. Analysis was performed by SPSS. The significance level of the statistical test was 0.05. Intravenously with a loading dose of 10 mg / kg and a maintenance dose of 1 mg / kg / h. Local was initially 1gr in 300 ml and 500 mg in 50 ml at the end. The amount of bleeding was the volume of the drain. 49 patients, 22 (44.9%) took the drug intra-venously and 27 (55.1%) locally.

There was no significant relationship between the groups in the amount of bleeding with the type of surgery (p: 0.48) with the surgical level and in the amount of total bleeding (p: 0.48) (p: 0.14). Bleeding rate of local group: intraoperative: 363.89 56 563.89 ml, postoper-ative: 116.30 ± 71.37 ml and total: 680.19 ± 394.83 ml , intravenous group: intraoperative: 496.64 ± 296.84 ml, postoperative: 75.84 120 120 ml Total: ml 616.64 ± was 311.45.

The results do not confirm the average amount of bleeding was similar in both groups.