The effect of obesity and supplementation of garlic extract along with aerobic activity on the expression of brain-derived neurogenic factor genes, tyrosine kinase B and short-term memory of male wistar rats.

The extent of cognitive impairment in obesity has been extensively researched for several years. Also, the effect of garlic extract and aerobic activity on these cognitive disorders in obese people is still unknown. Forty male Wistar rats were exposed to a high-fat diet for 12 weeks to induce obesity, and finally 30 obese rats were identified using the Lee index and then randomly divided into 5 groups: control, obesity, garlic, aerobic exercise, garlic + exercise. Were aerobically divided. Aerobic exercise including 30 minutes per day, 8 / m / min 5 days a week and garlic and stevia extract at a concentration of 250 mg / kg were added to the daily water intake. Brain tissue was sent to the laboratory to study gene expression by real-time PCR. One-way ANOVA and LSD post hoc test were used to determine the differences between groups and a significance level of 0.05 was considered. The results showed that compared to the control group, 12 weeks of high-fat diet increased the body weight of rats (p <0.05) and even during 8-week extract interventions and training, remained higher than the control group. . In addition, BDNF gene expression levels decreased significantly (P <0.05) and TrKB gene expression levels also increased significantly in 12 weeks of high-fat rats compared to the healthy control group (p <0.05). On the other hand, in the Y maze, the percentage of rotation in obese rats was significantly lower than the control group (p <0.05). Induction of a high-fat diet in childhood causes mild genetic changes in male Wistar rats, and the combination of aerobic and extractive physical activity appears to be more effective than aerobic and extractive interventions alone.