Effect of L-Carnitine Consumption and Endurance Training on Lung Tissue Structure Damage in Male Boldenone-Poisoned Rats

 Performing endurance training and taking L-carnitine supplements is effective in improving the performance of athletes, but its effect on repairing lung damage caused by boldenone injection is still unknown.

 The present study aims to assess the effect of L-carnitine consumption alone with endurance training on lung tissue structure damage in male rats poisoned with boldenone.

 In this experimental study, 30 male Wistar rats (weight= 228.53±7.94 g) were randomly divided into five groups: Control, boldenone, boldenone+training, boldenone+supplementation, and boldenone+training+supplementation. Boldenone (5 mg/kg) was injected in the biceps femoris once a week, and L-carnitine supplementation (600 mg/kg) was administrated in gavage into the stomachs of animals, three days per week. The endurance training program was included running on a treadmill for 8-week, three days per week, each for 30 minutes at a speed of 12 m/min, which reached 60 minutes and 30 m/min in the final week. Histopathological changes in bronchioles and alveoli were examined using a light microscope. 

 The weight ​​of two groups of boldenone+supplementation, and boldenone+training+supplementation increased significantly compared to the boldenone group (P=0.005). In the boldenone+training+supplementation group, a significant improvement in bronchioles and alveoli was observed compared to the boldenone group (P=0.001).

 It seems that performing endurance training along with L-carnitine supplementation has a great effect on reducing the destructive effects of boldenone on lung tissue.