OSTEOPOROSIS FREQUENCY AND ITS RELATIONSHIP WITH SERUM LEVEL OF VITAMIN K2 IN COLON CANCER PATIENTS BEFORE AND AFTER COLECTOMY

Colorectal cancer is one of the most common cancers of the gastrointestinal tract, caused by predisposing factors like lifestyle and aging, and partly, due to genetic and inherited disorders. Due to the increasing incidence of this cancer in Iran, the present study was designed to determine the prevalence of osteoporosis and its relationship with serum levels of vitamin K2 in the patients with colon cancer before and after colectomy.

In this descriptive-analytical study, 38 patients with colon cancer who underwent colectomy in Imam Khomeini Hospital in Urmia were included in the study.Demographic information, BMD, and vitamin K2 levels of the patients before and after colectomy were collected and recorded in a checklist. Data were analyzed using SPSS Version 17 statistical software.

From 38 patients with colorectal cancer, 34.2% were male and 65.8% were female. The mean age of the patients was 58.5 ± 12.7 years. Reviewing bone density examinations done by Dual Energy X-Ray Absorptiometry (DXA) in hip and spine of the patients showed that osteoporosis was higher in both places after colectomy, and their significant differences between them (P-Values were 0.043 for hip and P0.009 for spine).

The results of this study showed that osteoporosis in the hip and spine of the patients with colon cancer increased after colectomy compared to it before colectomy. However, the correlation between serum vitamin K2 levels and osteoporosis was not significant.