The Interaction of Gallic Acid and Swimming Training on Ovarian Histology in Rats with Polycystic Ovary Syndrome

Polycystic Ovary Syndrome (PCOS) is the leading cause of infertility due to lack of ovulation and the result of oxidative stress of ovarian tissue, which is associated with disability in ovarian functions. This study aims at evaluating the effect of 4 weeks of Gallic Acid (GA) prescription and swimming (EX) training on ovarian tissue parameters in PCOS model. Forty adult Wistar female rats weighing 180 ± 10 g were randomly divided into 5 groups: PCOS, PCOS + GA, PCOS + EX and PCOS + GA + EX. To induce the PCOS model, letrozole (1 mg / kg) was NG tubed for 28 days. Then, GA was prescribed orally for 4 weeks and swimming was performed for 4 weeks and 3 sessions per week. Finally, after dissection of the ovary and staining with hematoxylin-eosin, histological evaluations were performed. The results showed a significant decrease in corpus luteum diameter, number of monolayer, multilayer, secondary and Graafian follicles and corpus luteum in PCOS group and also a significant increase in the number of atretic and cystic follicles compared with control group. While the interaction of GA prescription and swimming improved ovarian parameters. However, no significant change in the diameter of oocytes and primary and multilayered follicles was observed in the groups. GA and swimming appear to be effective on restoring the folliculogenesis of PCOS rat model and the ovulation process.