Comparing the Effect of Administrating Dorzolamide and Timolol on Healing the Alkaline Corneal Infectious Ulcer in Rabbits

Corneal ulcer and its healing is one of the most controversial topics in medicine and veterinary fields. Glaucoma is recognized as the second cause of blindness in the world.  The aim of the present study was to investigate the microscopic effects of chemicals on the cornea and the practical purpose of this study was to compare the effect of two common antihypertensive drugs (Dorzolamide and Timolol) on the cornea affected by chemical burns performed in rabbits.

This study was experimental and thirty healthy white Newzeland male rabbits with an average weight of 2-3 kg and the age of 6 months were selected for the study. 10 rabbits were considered as the control group and 20 as the experimental group. In experimental group 1, which included 10 rabbits, one drop of Dorzolamide in the left eye was used twice a day, and in 10 rabbits of the experimental group 2, one drop of Timolol in the left eye was used twice a day. Five rabbits in each group on day 14 and 5 rabbits on day 21 were removed and their eyes were removed for histopathological examination.

The results of the study showed that Timolol was a better alternative to Dorzolamide for rabbits with glaucoma and Infectious corneal ulcers.

This study will provide a suitable solution for treating referrals of rabbits and other pets with corneal ulcers to veterinary clinics.