The role of moderate and high-intensity exercise training in prevention and treatment of breast cancer: A systematic review

  Breast Cancer is a disorder caused by unregulated cell growth in breast tissue which rises significantly in worldwide and it is currently the most common cancer diagnosed in women. The aim of the present study was to explore a systemic review on the effects of moderate and high-intensity exercise training on the prevention and treatment of breast cancer.

Related articles to the role of exercise training in the prevention and treatment of breast cancer and involved molecular pathways were searched from valid databases including Pub Med, Google Scholar, Scopus, SID, and ISC between 2000 to 2021 years.

In related studies to the effect of exercise training on breast cancer prevention in individuals at high risk for breast cancer, results demonstrated a 20% reduction in risk of breast cancer in women who have a high level of physical activity compared to sedentary women. The findings related to the effect of exercise training on controlling breast cancer progress, indicates that exercise training directly through the effect on tumor intrinsic factors and molecular mechanisms can control or improve breast cancer without any side effect.

Exercise training can be considered as an important intervention in the prevention and complementary treatment of breast cancer by inhibiting cancer cell proliferation, inducing apoptosis, suppressing angiogenesis, regulating the inflammation environment, and improving the side effects resulting from cancer treatment.