Investigation the concentration of interleukin-6, interleukin-10, and vitamin D in diabetic patients with covid-19 hospitalized in the intensive care unit

Anti-cytokine considerations and other treatments in covid-19 patients with a history of diabetes can play an important role in preventing mortality. Therefore, the aim of this study was to investigation the concentration of IL-6, IL-10, and vitamin D in diabetic patients with covid-19 hospitalized in the intensive care unit.

The statistical population of this research was all diabetic patients with covid-19 hospitalized in the special care department. 16 of them were selected as a statistical sample by the census. Cytokines were measured using a special kit for IL-6 and IL-10 based on the manufacturer's instructions, using the ELISA method. A level above 30 ng/dL of vitamin D was considered as a sufficient level, and a level below that was considered as an insufficient and deficient level. Independent t-test was used to compare two groups. In addition, to reveal the effect size in the independent test, Cohen's D effect sizes were calculated for each group. The significance level of all statistical operations was determined by SPSS at the P≤0.05 level. Graphs were drawn using Graph Pad Prism 9.

All diabetic patients infected with covid-19 suffered from vitamin D deficiency levels so, the level of vitamin D was between 10 and 20 ng/dl in all of them. Also, the results showed that the levels of both IL-6, IL-10 increased significantly in patients admitted to the intensive care unit compared to healthy individuals (P≤0.05).

It seems that measuring the level of IL-6, IL-10, and their ratio along with vitamin D can be used as a useful predictor to diagnosing special care measures in diabetic patients with covid-19.