Effect of Six Weeks of Resistance Training on Vascular Endothelial Growth Factor and Neuron Derived Neurotrophic Factor of Heart Tissue in Obese Male Rats

The phenomenon of angiogenesis in pathophysiological conditions such as obesity and physiological conditions such as exercise have different effects on the body. The aim of this investigation was to study the effect of six weeks of resistance training on Vascular endothelial growth factor and Neuron Derived Neurotrophic Factor in obese male rats. In an experimental study, 20 male wistar rats aged five weeks and weight approximately 120 to 160 grams, were divided into two equal groups, control and experimental, based on weight homogenization. The experimental group performed a training protocol for six weeks, three sessions per week, and each session includes one set of 10 repetitions with a 90-second rest interval, including of climbing a resistance training ladder at a height of one meter and an incline of 85 degrees with a weight attached to the base of the tail (with Paying attention to the maximum weight carrying capacity of each rat. 48 hours after the last training session, the rats were sacrificed and blood was taken from the heart. The values of VEGF and NDNF in the heart tissue were evaluated with ELISA method. In order to examine the changes of between groups, the independent t-test was used at a significance level of p<0.05. The results indicated that six weeks of resistance training led to a significant increase in VEGF values (p=0.0001) and a significant decrease in NDNF values (p=0.0001) in experimental group in comparison to the control group. Base on the findings of this study, it seems that resistance training can have positive effects on preventing the risk of cardiovascular diseases caused by obesity, by increasing some protective factors and reducing angiogenesis inhibitory factors.