The effect of high intensity interval training on reducing insulin resistance, serum asprosin and body fat percentage in obese men with type 2 diabetes

Asprosin is an adipokine that has a positive relationship with obesity and type 2 diabetes; also, this adipokine plays an important role in the pathogenesis of insulin resistance with its gluconeogenic and metabotropic effects. The aim of this study was to determine the effect of six weeks of high intensity interval training (HIIT) on insulin resistance, body fat percentage and asprosin serum in obese men with type 2 diabetes.

In this semi-experimental research, 24 obese men with type 2 diabetes were randomly divided into 2 HIIT and control groups. People in the training intervention group did six weeks of HIIT training with an intensity of 80-85% heart rate reserve in 3 training sessions per week. Blood and anthropometric variables were performed fasting 48 hours before and after the intervention. Paired sample t-tests and analysis of covariance were used for statistical analysis.

After the intervention, there was a significant difference (P<0.001) in serum asprosin (-10.47% vs. +0.13%), body fat percentage (-5.17% vs. +0.13%), and insulin resistance (-23.94% versus +10.02%).

According to the results, it can be said that adjustment of fasting asprosin to body fat percentage is one of the effective mechanisms for reducing insulin resistance in type 2 diabetes in adaptation to HIIT.