Correlation of STAT4 gene Polymorphism (rs3024839) with risk of myocardial infarction (MI)

 The present study was the effect of mindfulness therapy on the quality of life and sleep quality of patients with type 2 diabetes. This research is a semi-experimental study with a pre-test, post-test design with a control group.

 The statistical population of the research is type 2 diabetes patients referred to hospitals in Shiraz, from which 30 people (15 people in the experimental group and 15 people in the control group) were selected based on the objectives and hypotheses of the research. In the current research, to collect data from the World Health Organization's Quality of Life Questionnaire (1996); Boyce et al.'s sleep quality (1989) and 8 sessions of 90-minute mindfulness therapy (Rodriguez-Romero and Smith, 2022) were implemented on the sample group. The collected data were analyzed in SPSS24 software based on covariance analysis.

 The results showed that there is a significant difference between the average quality of life and sleep quality in the experimental and control groups. Based on this, it can be said that mindfulness treatment in the post-test has increased the scores in the overall quality of life and decreased the scores in the quality of sleep in patients with type 2 diabetes.

 It seems likely that the rs3024839 T/C polymorphism of STAT4 gene plays an important role in the incidence of MI. However, more studies with a larger sample size are necessary to confirm the results of the present study.