INVESTIGATION THE POSSIBLE EFFECT OF INTRAPERITONEAL INJECTION OF CRACK-COCAINE AND METHAMPHETAMINE ON KIDNEY FUNCTION IN MALE WISTAR RATS.

Crack is a solid salt processed with sodium bicarbonate from cocaine. Methamphetamine is a derivative of methylamphetamine, which is highly addictive. The current study aims to investigate the effect of intraperitoneal injection of crack cocaine and methamphetamin over the parameters of blood creatinine, urea, sodium, and potassium as indicators of kidney failure in male rats.

This experimental study was carried out over seven groups of 6 male rats, including a control group, three crack-cocaine experimental groups, and three methamphetamine experimental groups, each of them receiving concentrations of 5, 10, and 15 mg/kg of crack-cocaine or methamphetamine respectively for 7 days (once a day). After the drug injection, blood was taken from the hearts of the rats and the parameters of urea, sodium, potassium, and creatinine were measured and analyzed from the blood samples taken. Statistical analysis of the data was done with the one-way analysis of variance and Tukey's post hoc test via SPSS.

The injection of low and medium concentrations of two drugs, crack cocaine and methamphetamine, had no significant effect on the mentioned parameters (P > 0.05), and only the medium concentration of methamphetamine caused the amount of blood potassium to increase compared to the control group (P < 0.05). Injection of 15 mg/kg concentration of both drugs significantly increased the amount of blood creatinine in the respective groups (P < 0.05).

The increase in plasma creatinine due to the administration of methamphetamine and crack-cocaine may be caused by acute renal failure, rhabdomyolysis, or the induction of acute interstitial nephritis.