Evaluation of serum vitamin D level, neutrophil to lymphocyte ratio and mean platelet volume in patients with recurrent aphthous stomatitis

  Recurrent Aphthous Stomatitis (RAS) is a disorder characterized by recurrent ulcers limited to oral mucosa in patients who have no other symptoms of systemic disease. The main factors currently associated with RAS include genetic factors, hematological defects, immunological problems and local conditions such as trauma and smoking. The aim of this study was to evaluated serum vitamin D levels, neutrophil to lymphocyte ratio and mean platelet volume in patients with RAS.

 In this case control study, 30 patients with RAS and 30 healthy individuals were compared as controls, serum samples were evaluated for vitamin D, neutrophil to lymphocyte ratio and mean platelet volume. Findings were analyzed by Mann- Whitney and sample-t-test.

 Serum vitamin D levels in patients with RAS were 21.44±12.09 ng/ml  and in healthy individuals were 24.87 ±18.65 ng/ml . Also neutrophil to lymphocyte ratio in patients with RAS were 1.89± 1.23  and in healthy individuals were 2.03± 1.79. Mean platelet volume in patients with RAS were 10.36± 0.93 fl and in healthy individuals were 10.65 ±1.12 fl . There was no significant difference between the two groups. All three markers were not significantly different between the two groups. respectively (P=0.4), (P=0.8) and (P=0.27)

It seems that serum vitamin D levels and neutrophil to lymphocyte ratio and mean platelet volume not statistically significant in patients with RAS and healthy individuals.