Effect of Combined Training along with Caffeine Supplementation on Plasma Asprosin in Middle-Aged Obese Men

In obesity, the serum levels of Asprosin are pathologically upregulated, this is thus considered a therapeutic target. This study aimed to explore the effect of exercise training as combined training (Aerobic+ Resistance training) along with Caffeine supplementation on the plasma levels of Asprosin in middle-aged obese men. 38 obese men aged 35 to 50 years, with a BMI of greater than 28 participated in the research. They were stratified randomized into 4 groups. including: 1-Control-placebo (n=10), 2- Caffeine (n=10), 3- Combined training-placebo (n=9) and 4- Caffeine and combined training (n=9). The caffeine group consumed the caffeine tab 4.5 mg per kg body weight, daily, for 6 weeks. The Combined training group had concurrent aerobic and resistance training for 6 weeks (3 sessions per week). Blood samples were collected before and after the intervention, and the plasma asprosin concentration was measured by the ELISA method. By the effect of the Combined training, the Asprosin level was reduced (p=0/01). Taking Caffeine alone did not significantly reduce Asprosin (p=0/19). The Asprosin declined in the group that had both Combined training and Caffeine (p=0/01). In order to reduce the upregulated Asprosin in obese individuals known as pathologic, combined training is recommended and/so it is not necessary to take caffeine along with the training.