Hepatoprotective effects of silybum marianum and callendula officinalis polyphenolic extracts in rat

Plants consumed humans contain thousands of phenolic compoounds. The effects of dietary polyphenols are of great current interest due to their antioxidative and possible anticarcinogenic activities. Liver is one of the organ in body that exposure with many of oxidant and carcinogen agents thus antioxidant compounds are beneficial for liver healt. In this study was investigation protective effects of silybum marianum and caliendula officinalis against thioacetamide-induced hepatotoxicity in rat. After extraction and purification, the extracts were injected at a dosis of 25mg/Kg together with thioacetamide at a dosis of 50mg/Kg (P.C.). After blood collection and separation of serum, activities of aminotrasferases (SGOT and SGPT), alkalin phosphatas, Bilirubin, Na+ and K+were measured in serum. Significant decrease in activity of aminotrasferases, alkalin phosphatas and Bilirubin were observed in groups treated with extracts in compared with thioacetamide treated group. These result show that protective effects of these extracts against the thioacetamide induced hepatotoxicity that may be due to its ability to block the bioactivation of thioacetamide, primarily by inhibitig the activity of Cyt P450 and its free radical scavenging.