Accuracy of Frozen Section in Diagnosis of Ovarian Mass in Isfahan Medical Hospital 2005

Malignant ovarian tumor is one of the most fatal gynaecologic malignancies. Of all the gynecologic cancers, ovarian malignancies represent the greatest clinical challenges. It has the highest fatality to case ratio of all the gynecologic malignancies. To provide optimal management of a patient with an adnexal mass, it is important to differentiate between malignant and benign pathology prior to and during surgery. Preoperative discrimination between the malignant and benign adnexal mass can be made with patient characteristics such as age, menopausal status, sonography and CA125 level in the peripheral blood. Frozen section has long been used as a diagnostic tool for intraoperative histopathologic determination of various surgical conditions and has an acceptable accuracy for clinical use, including gynecological diseases. The accuracy of the technique has been reported. The aim of the present study was to examine the accuracy of frozen section diagnosis of adnexal mass in Isfahan University. This is a descriptive study done in Isfahan in 2005. A total of 45 surgically removed ovarian tumors were studied. Each ovarian tumor sample was evaluated for histopathologic diagnosis using both Frozen section and paraffin seethes. Interpretation was separate and blinded to benign and malignant in each technique. From 45 patients of whom 68.8% had a benign tumor, 31.2% had a malignant tumor at definitive histological assessment. Sensitivity of frozen section for benign and malignant tumors was 100% and 88.5% respectively. Specificity of frozen section for benign tumors was 88.5%, and for malignant tumors 77%. Frozen section appears to be an accurate technique for the histopathologic diagnosis of ovarian tumors.