Association between the level of HbA1c & serum lipids profile in type 2 diabetic patients

Impaired lipid metabolism in diabetic patients is implicated in cardiovascular complications. The aim of this study was to evaluate the effect of glycemic control on the lipid profile of type 2 diabetic patients. This study was performed at Emam Reza Hospital, Mashhad, Iran, in 2006. A total of 357 adults with type 2 diabetes (144 males and 213 females) were evaluated. This study was approved by the local committee of medical Ethics. In the standard condition, the sera analysed for fasting blood glucose (FBG) by glucose oxidase method, and for total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) by enzymatic methods, and for HbA1c by chromatography method. The data analyzed by (SPSS, version 11.5), Pearson’s correlation test, t test and one- way analysis of variance. P values ≤ 0.05 considered significant. The level of HbA1c, Triglycerides and FBG did not differ significantly between males and females, however, the level of cholesterol, LDL-C, and HDL-C were significantly higher in females. There was a significant correlation between FBG and HbA1c. A direct association of FBG and HbA1c with total cholesterol and triglycerides observed, however, they were not correlated with LDL- C and HDL-C. The level of serum triglyceride was considerably higher in patients with inadequate glycaemic control. This study clearly shows that, HbA1c not only is a reliable biomarker of glycemic control but also, a good predictor of the serum lipid profile in diabetic patients.