Genetic Linkage Analysis of HDL-C in 91 Iranian families with metabolic syndrome with Haseman-Elston Regression methods

Metabolic Syndrome (Mets) is a common phenotype, which is affected on 32% of Iranian population. It is associated with an increased risk for cardiovascular disease. Low HDL-C is the most frequent phenotype in this disease.

In this study in order to find some chromosomal region in related to the HDL-C in families with metabolic syndrome, twelve microsatellite markers were investigated in 91 families and done the Haseman-Elston Regression methods (oHE, sHE, rHE, W2, W3, tHE). Finally, the results of these methods are compared. For analysis of the data, these softwares were used: power.HE (in R), Excel, PowerMarker, SPSS, S.A.G.E.

In results of 4 methods, from these 7 methods, genetic linkage of HDL-C is significant with D11S1998 marker (p<0.05).

Other studies also show this result.These results can help me in future studies in Iranian population. Results show in which theoretical power of these methods is better, the empirical significance become less and this is an evidence for accepting significant linkage between D11S1998 marker and location of HDL-C gene.