The Correlation between Ki67 Proliferative Marker and the Reactivity and Site of Cervical Intraepithelial Lesions

Cervical intraepithelial neoplasia and cancerous lesions are spectrum of morphologic changes without having definite boundaries. Immunohystochemical methods and proliferative markers are among the reliable ways in classifying the various lesions of cervical dysplasia. In related literature ki67 proliferative marker is known as a prognostic factor in the progression of cervical cancerous lesions. This research was performed to propound a more detailed classification of CIN using expression of Ki67 proliferative marker.

In this cross-sectional descriptive-analytical study 42 cervical biopsies (mild dysplasia N=16, moderate dysplasia N=8, severe dysplasia N=10 cervical normal tissue N=8) were selected from Pathology archive of Ghaem Hospital in Mashhad in year 2007, and the expression of Ki67 proliferative marker was analyzed hystochemically in paraffinized slides. Then the relationship between the severity of dysplasia, the location of expression of Ki67, and the reactivity of the cervical dysplasia was examined. Data was analyzed by SPSS11 and using ANOVA tests.

The direct relationship between the severity of dysplasia changes and the site and reactivity of cervical intraepithelial lesions was observed by using the expression of KI67 marker

Evaluating intraepithelial cervical lesions by Immunohistochemistry methods and Ki67 marker is a reliable method for diagnosis and classification of various dysplastic lesions.