Influence of Topical Diclofenac Sodium on Ocular Hypotensive Effect of Latanaprost in Normal Subjects

According to extensive use of latanoprost in treatment of glaucoma and increasing administration of Non Steroidal Anti Inflammatory Drug, (NSAIDs) in ophthalmology, this question comes important to answer that what is NSAIDs effects on Latanoprost intra ocular pressure (IOP) lowering properties. Our purposes are to evaluate the effect of Diclofenac Sodium0.1%on IOP reduction by latanoprost0.005% and to evaluate the effect of Diclofenac Sodium0.1% on IOP without co-administration of Latanoprost0.005%. 42 eyes of 21 patients were enrolled in this study. First for one eye of subjects Latanoprost0.005 eye solution and for other eye artificial tear administered for 4 weeks. Then Diclofenac Sodium0.1% eye solution was administered for 2 weeks for both eyes and then changes of mean IOP in each group were surveyed. Usage of Diclofenac Sodium0.1% eye solution is discontinued and 2 weeks later the changes of mean IOP in each group were surveyed again. In co-administration of Latanoprost and Diclofenac Sodium0.1%, mean IOP increased from 1 4.38 to 15.52 mmHg after administration of Diclofenac Sodium0.1 %. This change was significant (P=0.03).In the other eye mean IOP was decreased from 15.33 to 14.81 mmHg after Diclofenac Sodium0.1% administration. This change was not significant (P=0.205) Diclofenac Sodium0.1% decreases the IOP lowering effect of Latanoprost while Diclofenac Sodium0.1% doesn’t have significant influence on IOP alone. (without co-administration of Latanoprost).