مجله دانشگاه علوم پزشکی شهید صدوقی یزد
سال سی و یکم شماره 9 (پیاپی 205، آذر 1402)

After the outbreak of the Coronavirus and the epidemic of its attributed disease worldwide, many scientists decided to use new strategies to diagnose, prevent and treat the coronavirus-caused disease. Nanotechnology, with a wide range of applications in various sciences, including medicine, helps to progress and solve many of its problems. Nanosystems with unique features have a special place in drug delivery and biomolecule transport. They can transfer antiviral and other drugs that face the coronavirus through different mechanisms in the blood plasma and between cells. Likewise, viral components and antibodies against them are moved between cellular and subcellular boundaries by some of these systems.

This study investigated the application of nanosystems in targeted drug delivery, vaccination, and diagnosis of corona disease.

Treatment of head and neck cancers, it can have adverse effects on patients' oral health status. The aim of this study was to assess the level of knowledge and practice of general dentists in Yazd City in the field of oral care in patients undergoing chemotherapy and radiotherapy.

In this descriptive cross-sectional study, 134 general dentists were selected by systematic random sampling and their awareness and practice level were assessed using by using a researcher-made questionnaire with valid and reliable questionnaire (r=0.81). Data were analyzed using SPSS software version 25, t-test and ANOVA tests.

The mean score of knowledge score was 11.44 ±2.03 out of18 and mean of practice score was11.9 ±3.41 out OF 20. The mean score of knowledge was not significantly associated with age, work experience and practice score were not significantly associated with gender, age and work experience, but the mean score of knowledge in women was significantly higher than men (P=0.01). Moreover, dentists worked in both clinic and Personal office showed significantly higher awareness (P=0.001). The average practice score of dentists in personal office was significantly higher than other options (P=0.03).

Dentists of Yazd had moderate knowledge and performance level in the field of oral and dental care in patients undergoing chemotherapy and radiotherapy. It seems that the need to hold programs with this theme in the sessions of continuing education and holding training and educational webinar to improve the level of awareness and clinical practice to provide desirable services to these patients should be considered.

Canalis Sinuosus (CS) is a bony canal in the upper jaw.  This canal has branches towards the anterior ridge and the teeth, which can be exposed to damage during dental procedures such as implants, resulting in paranesthesia. The purpose of this study was to determine the frequency of CS in the anterior region of the maxilla by CBCT radiography in a private radiology center in Yazd City in the last 2 years, to familiarize dentists with this anatomical variety and prevent complications.

In this cross-sectional study, 218 CBCT images were selected. Images are related to the patients in the age range of 24 to 80 years. Axial, coronal and sagittal sections are reconstructed by an oral and maxillofacial radiologist. The images reviewed by two radiologists. Then, age, sex, frequency, location of the canal ending, bilateral or unilateral, sub-branches and the location of the canal in the vertical and anteroposterior dimension were checked. The results were investigated by SPSS version 16 software with Chi squared and T-test statistical tests.

The reviewed images belonged to 112 (51.4%) women and 106 (48.6%) men. The frequency of CS was 96.3%. The most frequency was found in women in the age of 24-44 years (62.8%). The 95.4% was reported bilaterally. In the examination of the Accessory canals, they were not seen in 141 people (64.7%). The accessory canal (AC) was reported more frequent between central and lateral incisor. In this study, using the Chi-Square test, there was no statistically significant relationship between the presence of CS and age (P=0.188) and gender (P=0.162).

Due to the high frequency of CS and its branches in the anterior region of the maxilla, in order to avoid unwanted consequences during surgery, the desired area should be examined.

 Dentigerous cyst and odontogenic keratocyst (OKC) are two of the most common developmental odontogenic cysts. Different developmental mechanism and biological behavior of OKC is due to unknown factors inherent in the epithelium or enzymatic activity in the wall. P53 plays a role in determining the pathways for DNA repair، apoptosis، angiogenesis and genomic stability and is negatively confronted with the MDM2 oncoprotein. Aim of this study was to evaluate the expression of MDM2 as an important indicator of proliferation and cell cycle regulation in OKC and dentigerous cyst.

 In this descriptive-cross-sectional study، MDM2 expression in the suprabasal and basal epithelium regions of 15 samples from each of the dentigerous cysts and OKC was assessed using immunohistochemistry. Finally، the data were entered into the SPSS16 software and analyzed using the t-test.

 MDM2 expression in the suprabasal and basal epithelium regions in OKC was higher than dentigerous cyst، but there was not seen a statically significant difference (P: 0.551)، (P: 0.825). The expression level of this marker in both groups in the suprabasal region was significantly higher than the basal region (P: 0.005)، (P: 0.004).

 Higher expression of MDM2 in OKC، especially in the suprabasal areas، could indicate a secondary role of this protein in the pathogenesis، growth and spread of this cyst and the proliferation، apoptosis and differentiation processes confirm the neoplastic nature and specific biological behavior of this lesion.

The rational use of drugs is one of the main elements of achieving the best pharmacotherapy method for patients. Linezolid is used for infections caused by gram-positive bacteria, including vancomycin-resistant staphylococci and vancomycin-resistant enterococci, but the inappropriate use of this drug has led to the emergence of linezolid-resistant strains. The purpose of this study was to investigate the manner of Linezolid prescription in Shahid Chamran Hospital of Isfahan City in 2021.

This cross sectional study was conducted during a period of 6 months (From September 1, 2021 to February 31, 2022) on 102 patients admitted to Shahid Chamran Hospital in Isfahan City. Patient information such as demographic information, indication and dosages of drugs, the basis of drug prescription, side effects and drug interactions, etc. were extracted from the medical records of patients and hospital systems and recorded in designed forms. After matching the information with the relevant guidelines, statistical analysis was performed using SPSS-16 software.

Out of the 102 patients, who received linezolid, 75.1% were men and the rest were women. 99% of the cases were prescribed experimentally and 1% was based on culture. In 40.2% of the patients, drugs were prescribed irrationally in terms of prescription indications. In 84.3% of the cases, a change in treatment regimen was observed after receiving the culture results.

A large percentage of cases of linezolid drug prescription was not done correctly. Furthermore, it has not been attention to the side effects caused by the drug, especially thrombocytopenia.

Over the past few decades, the phenomenon of addiction has increased all over the world for various reasons. The aim of this study was to investigate structural modeling of the relationship between spiritual health with addiction tendency in adolescents with the mediating role of emotional well-being.

This research was descriptive-correlation based on the model of structural equations. The statistical population of this research included all the male students of the second secondary level of public high schools in Rasht City in the year of 2021. From this community, 300 qualified volunteers have been selected for the study by the multistage cluster sampling method. Three standard questionnaires, including Paloutzian and Ellison Spiritual Well-Being Scale (1982), Keyes and Magyar-Moe subjective well-being (2003), and Mousavi et al Addiction Tendency Scale (2008) were used for data collection. Evaluation of the proposed model was done through structural equations; amos24 software was utilized to analyze the findings.

The results showed that the relationship between spiritual health and addiction tendency, also relationship between emotional well-being and addiction tendency were negative and significant (P<0.01). The relationship between emotional well-being and spiritual health was positive and significant (P<0.01). In the meantime, the indirect path of emotional well-being was significant in the relationship between spiritual health and addiction tendency (p<0.01). Finally, all the fit indexes were at an optimal level.

This research confirms the mediating role of emotional well-being in the relationship between spiritual health and addiction tendency. It is hoped that families and guardian organizations will benefit from the results of this research.

In this study, we examined the impact of a hydroethanolic extract derived from ajwain and carvone (a compound present in ajwain), on learning, spatial memory, and anxiety levels in adult male rats that were chronically immobilized.

There were 60 rats used in this study, divided into six groups of 10 rats each. To expose stress, 30 rats (in 3 groups including Stress, Stress-Carvone, and Stress-Ajwain groups) were placed in a restrainer for 6 hours every day for 21 consecutive days. Stress-Carvone and Stress-Ajwain groups received carvone (20 mg/kg) and ajwain extract (500 mg/kg) by gavage respectively. Thirty rats were also used in three groups (Control, Carvone, and Ajwain groups). Spatial learning and memory were studied using the Morris water maze, and anxiety was assessed by the elevated-plus maze.

Compared to the control group, chronic immobilization caused the rats to swim a longer time (P < 0.01) and distance (P < 0.05) to reach the hidden platform, and a shorter time and distance to swim in the target quarter (P < 0.05) in the Morris water maze. The percentage of entering the open arm in the elevated plus maze (P < 0.001) and the percentage of time staying in this arm (P < 0.01) were lower than the control group.  The carvone improved the performance of stressed animals in the Morris maze, but the ajwain extract had no effect on the memory deficit of stressed animals. Furthermore, treating ajwain extract and carvone increased the percentage of entry into the open arm and the percentage of time spent in the open arm in animals exposed to stress.

Ajwain extract and carvone reduce anxiety behavior in rats exposed to chronic immobility stress; carvone treatment prevents memory impairment in these animals. It is possible that the extract of ajwain (partially through carvone) is effective in reducing damage caused by stress in the nervous system.

Bacteriocins are peptides with antimicrobial properties. They are ribosomally synthesized and produced by both gram-positive and gram-negative bacteria. The bacteriocins produced by Escherichia coli are called colicins. Colicins in commensal bacteria inhibit the growth of pathogenic bacteria and in pathogen strains, they increase bacterial virulence. The aim of this study was to evaluate the frequency of col V and col Ia genes in Escherichia coli specimens isolated from patients with urinary tract infections in Yazd City, Iran.

In this descriptive cross-sectional study, 160 Escherichia coli samples were isolated from urine specimens and identified by common biochemical tests. The amplification of col V and col Ia genes was performed by PCR method using specific primers and after sequencing, the results were analyzed using SPSS version 16 software.

In this study, out of 160 Escherichia coli isolates examined, calicin gene was detected in 26.9% of the isolates. The frequency of col Ia gene was 24.4% and the frequency of col V gene was 10.6%. Furthermore, in 8.12% of isolates, both genes were identified together. The frequency of isolates containing only col Ia gene was 16.2% and isolates containing only col V gene was 2.5%.

In this study, isolates with col Ia gene showed high frequency. Most strains with col V gene also had col Ia gene. Therefore, the col V gene is often observed together with the col Ia gene.